Covers advanced genetic and molecular methods and their use in analysis of complex biological phenomena such as development, signaling, behavior, and disease. Discusses how these techniques are applied across an array of organisms, with special emphasis on the major eukaryotic genetic model systems (Drosophilia, nematodes, mouse, yeast, Arabidopsis). Uses primary research literature to analyze the design of forward? and reverse?genetic approaches to discover novel gene function. For advanced undergraduates and beginning graduate students. Prerequisite for undergraduates: BIOL 0470 or instructor permission. Expected background: any of BIOL 0280, 0500, 1050, or 1310. Graduate students should register for BIOL 2540.