Genetic mutations provides a powerful approach to dissect complex biologic problems. We will focus on fascinating discoveries from "forward genetic" studies ? moving from nervous system phenotype to genetic mutation discovery. There will be an emphasis of neurologic disease phenotypes and the use of novel genomic methods to elucidate the central molecular and cellular causes for these conditions. The course will emphasize the use of "reverse genetics" ? engineered mutations in model systems ? to dissect nervous system function and disease mechanisms. Disorders to be covered include autism, intellectual disability, schizophrenia, epilepsy. Enrollment limited to 20. Instructor permission required.