A double-credit graduate course on multidisciplinary experimental approaches to biological questions. Focusing on primary literature, lectures and discussions cover the mechanisms and regulation of basic cellular processes involving nucleic acids (synthesis, structure, maintenance and transmission) and proteins (synthesis, maturation, function) and their integration into more complex circuits (signaling, organelle biogenesis and inheritance, cell cycle control). Discussion section is required. Required for PhD students in the MCB Graduate Program; all others must obtain instructor permission. Enrollment is limited to graduate students.